| Product Name | CHAF1A Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CHAF1A |
| Synonyms | CAF 1 antibody; CAF 1 subunit A antibody; CAF antibody; CAF I 150 kDa subunit antibody; CAF I p150 antibody; CAF-1 subunit A antibody; CAF-I 150 kDa subunit antibody; CAF-I p150 antibody; CAF1 antibody; CAF1A_HUMAN antibody; CAF1B antibody; CAF1P150 antibody; CHAF1A antibody; Chromatin assembly factor 1 subunit A antibody; Chromatin Assembly Factor 1 Subunit A p150 antibody; Chromatin assembly factor I (150 kDa) antibody; Chromatin assembly factor I 150 kDa antibody; Chromatin assembly factor I p150 subunit antibody; DCAF1 antibody; hp150 antibody; MGC71229 antibody; P150 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human CAF1A. |
| Isotype | IgG |
| Target | CHAF1A |
| Reactivity | Human, Mouse |
| Applications | ELISA, IF, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q13111 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci By similarity. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Dong H., Gene 264:187-196(2001) [PubMed: 11250073]. Grimwood J., Nature 428:529-535(2004) [PubMed: 15057824]. Kaufman P.D., Cell 81:1105-1114(1995) [PubMed: 7600578]. |
| Supplier | Cusabio |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
