| Product Name | Chemerin-9 |
|---|---|
| Description |
Chemerin-9 is a nonapeptide corresponding to amino acids 149-157 of the C terminus of processed chemerin, which retains most of the agonist activity of the full-size protein towards the chemokine-like receptor 1 (CMKLR1) with an EC50 of 7.1 nM. Chemerin-9 significantly suppresses TNF-α-induced mRNA expression of adhesion and pro-inflammatory molecules in human umbilical vein endothelial cells (HUVECs) and significantly attenuates TNF-α-induced adhesion of THP1 monocytes and the macrophage inflammatory phenotype. In Apoe -/- mice, a 4-week infusion of chemerin-9 significantly decreases aortic atherosclerotic lesions. |
| Synonyms | Chemerin 149-157, Chemerin-9 (human), Chemerin C-terminal peptide |
| Molecular Weight | 1063.18 Da |
| Target | Chemerin receptors |
| Amino Acid Sequence | YFPGQFAFS |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 676367-27-4 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Wittamer et al (2004) The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J Biol Chem. 279(11) 9956 PMID: 14701797Sato et al (2019) Chemerin-9, a potent agonist of chemerin receptor (ChemR23), prevents atherogenesis. Clin Sci (Lond). 133(16) 1779 PMID: 31399499Kasimu (2020) Regulatory effect of chemerin and therapeutic efficacy of chemerin€‘9 in pancreatogenic diabetes mellitus. Mol Med Rep. 21(3) 981 PMID: 31922216 Related areasAll peptides >All chemerin receptor modulators >All adhesion molecule research categories >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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