| Product Name | CHI3L1, 22-383aa, Human, Baculovirus |
|---|---|
| Description | CHI3L1, also known as chitinase-3-like protein 1, is a member of the glycosyl hydrolase 18 family. This protein can bind heparins, probably as heparin sulfate. It has been found to enhance cell adhesion and promote cell signaling, proliferation and tumor angiogenesis. Elevated serum CHI3L1 levels occur in some conditions characterized by inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. Recombinant human CHI3L1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques |
| Synonyms | Chitinase-3-like protein 1 , CHI3L1, ASRT7, CGP-39, GP-39, GP39, HC-gp39, hCGP-39, HCGP-3P, YKL-40, YYL-40, 39 kDa synovial protein, ASRT7, Cartilage glycoprotein 39 CGP-39, CGP39, CH3L1_HUMAN, CHI3L1, chitinase chitinase 3 like 1, chitinase 3 like 1 (cartilage glycoprotein 39), Chitinase 3 like protein 1 precursor Chitinase-3-like protein 1, Chondrocyte protein YKL40 GP 39, GP-39, GP39, HC gp39, HCGP 3P, hCGP-39 HCgp39, YKL 40, YKL-40, YKL40, YYL 40 |
| Host | Virus |
| Molecular Weight |
45.9kDa (416aa) 40-57kDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | YKLVCYYTSW SQYREGDGSC FPDALDRFLC THIIYSFANI SNDHIDTWEW NDVTLYGMLN TLKNRNPNLK TLLSVGGWNF GSQRFSKIAS NTQSRRTFIK SVPPFLRTHG FDGLDLAWLY PGRGDKQHFT TLIKEMKAEF IKEAQPGKKQ LLLSAALSAG KVTIDSSYDI AKISQHLDFI SIMTYDFHGA WRGTTGHHSP LFRGQEDASP DRFSNTDYAV GYMLRLGAPA SKLVMGIPTF GRSFTLASSE TGVGAPISGP GIPGRFTKEA GTLAYYEICD FLRGATVHRI LGQQVPYATK GNQWVGYDDQ ESVKSKVQYL KDRQLAGAMV WALDLDDFQG SFCGQDLRFP LTNAIKDALA ATLEHHHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Hakala BE., et al. (1993) J Biol Chem 268:25803-25810. Eurich K., et al. (2009) World J Gastroenterol. 15:5249-5259. |
| Background | CHI3L1, also known as chitinase-3-like protein 1, is a member of the glycosyl hydrolase 18 family. This protein can bind heparins, probably as heparin sulfate. It has been found to enhance cell adhesion and promote cell signaling, proliferation and tumor angiogenesis. Elevated serum CHI3L1 levels occur in some conditions characterized by inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. Recombinant human CHI3L1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques |
| Supplier | ARP |
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