| Product Name | Chicken Caveolin-1 (CAV1) ELISA Kit |
|---|---|
| Description | The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. This assay has high sensitivity and excellent specificity for detection of Chicken CAV1. No significant cross-reactivity or interference between Chicken CAV1 and analogues was observed. |
| Synonyms | BSCL3, CAV, CGL3, MSTP085, VIP21, caveolae protein, 22-kD|caveolin 1|caveolin 1, alpha isoform|caveolin 1, beta isoform|cell growth-inhibiting protein 32 |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.064 ng/mL |
| Reactivity | Chicken |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. |
| Supplier | Abebio |
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