| Product Name | Chorionic Gonadotropin alpha (hCG), human |
|---|---|
| Description | Recombinant human chorionic gonadotropin (rhCG) rhCG is a heterodimeric, glycoprotein chain consisting of two on-covalently linked subunits - designated ? and ? consisting of 92 and 145 amino acid residues (237 a.a. total, Mw: 36.7kDa), respectively, with carbohydrate moieties linked to ASN-52 and ASN-78 (on ? subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on ? subunit). The primary structure of the ? chain of r-hCG is identical to that of the ? chain of hCG, FSH and LH. The glycoform pattern of the ? subunit of r-hCG is closely comparable to urinary derived hCG (u-hCG), the differences mainly being due to the branching and sialylation extent of the oligosaccharides. The ? chain has both O and N-glycosylation sites and its structure and glycosylation pattern are also very similar to that of urinary hCG. |
| Synonyms | Casein Kinase 2 Holoenzyme, CK2h. |
| Biological Activity | The biological activity of choriogonadotropin alfa is determined using the seminal vesicle weight gain test in male rats described in the Chorionic Gonadotrophins" monograph of the European Pharmacopoeia. The in vivo biological activity of choriogonadotropin alfa has been calibrated against the third international reference preparation IS75/587 for chorionic gonadotropin.The specific activity was found to be 26,000IU/mg. |
| Form | Purified, in 105mg sucrose and 3.43mg phosphoric acid |
| Concentration | 0.5 mg/ml |
| Purity | > 99%, as determined by: (a) Analysis by RP-HPLC and Anion-exchange FPLC. (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel |
| Storage | -2°C (aliquot), avoid repeated freeze and thaw cycles |
| Supplier | ARP |
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