| Product Name | CHP2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CHP2 |
| Synonyms | CHP2 antibody; HCA520Calcineurin B homologous protein 2 antibody; Hepatocellular carcinoma-associated antigen 520 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of humanCHP2. |
| Isotype | IgG |
| Target | CHP2 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | O43745 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. Loftus B.J., Genomics 60:295-308(1999). Wang Y., J. Immunol. 169:1102-1109(2002). Pang T., J. Biol. Chem. 277:43771-43777(2002). |
| Supplier | Cusabio |
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