| Product Name | CIITA Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CIITA |
| Synonyms | C2TA antibody; C2TA_HUMAN antibody; CIITA antibody; CIITA IV antibody; Class II major histocompatibility complex transactivator antibody; Class II transactivator antibody; MHC class II transactivator antibody; MHC class II transactivator type III antibody; MHC2TA antibody; NLR family acid domain containing antibody; NLRA antibody; Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from internal of human CIITA. |
| Isotype | IgG |
| Target | CIITA |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | P33076 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Steimle V., Cell 75:135-146(1993). Al-Kandari W., J. Mol. Biol. 369:1175-1187(2007). Al-Kandari W., Mol. Immunol. 44:311-321(2007). Croager E.J., Biochim. Biophys. Acta 1353:231-235(1997). |
| Supplier | Cusabio |
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