| Product Name | CISD2-Specific Monoclonal Antibody |
|---|---|
| Description | CISD2 gene encodes a 15 kDa CDGSH iron-sulfur domain-containing protein 2,which is also named Miner1 or NAF-1,this protein was reported on endoplasmic reticulum membrane or mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2),a rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. CISD2 regulates autophagy program by interacting BCL2,contributing to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. This monoclonal antibody is specific to CISD2 and does not cross-react with CISD1. |
| Synonyms | CDGSH iron sulfur domain 2,CDGSH2,CISD2,CISD2-Specific,ERIS,Miner1,MitoNEET related 1 protein,NAF 1,WFS2,ZCD2 |
| Host | Mouse |
| Clone | 569 |
| Immunogen | Fusion protein of Fusion Protein |
| Isotype | IgG2b |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q8N5K1 |
| Background | CISD2 gene encodes a 15 kDa CDGSH iron-sulfur domain-containing protein 2,which is also named Miner1 or NAF-1,this protein was reported on endoplasmic reticulum membrane or mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2),a rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. CISD2 regulates autophagy program by interacting BCL2,contributing to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. This monoclonal antibody is specific to CISD2 and does not cross-react with CISD1. |
| Supplier | Elabscience |
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