| Product Name | CK-17 Monoclonal Antibody |
|---|---|
| Description | Cytokeratin 17 (CK17) has a molecular weight of 46 KDa and is mainly marked on the basal cells of stratified epithelium and stratified epithelium, and myoepithelial cells of mammary gland and sweat gland. It is mainly used for the diagnosis of lung, cervix and oral squamous cell carcinoma.Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair.Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway . Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors . May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| Synonyms | Keratin, type I cytoskeletal 17 ,39.1,Cytokeratin-17,CK-17,Keratin-17,K17 |
| Host | Mouse |
| Clone | 5C1 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of CK-17 |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | Q04695 |
| Background | Cytokeratin 17 (CK17) has a molecular weight of 46 KDa and is mainly marked on the basal cells of stratified epithelium and stratified epithelium, and myoepithelial cells of mammary gland and sweat gland. It is mainly used for the diagnosis of lung, cervix and oral squamous cell carcinoma.Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair.Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway . Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors . May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| Supplier | Elabscience |
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