| Product Name | CLU Antibody, Biotin conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against CLU conjugated to Biotin |
| Synonyms | 40 antibody; AAG 4 antibody; AAG4 antibody; Aging associated protein 4 antibody; Aging-associated gene 4 protein antibody; AI893575 antibody; APO J antibody; Apo-J antibody; APOJ antibody; ApoJalpha antibody; ApoJbeta antibody; Apolipoprotein J antibody; ApolipoproteinJ antibody; CLI antibody; CLU antibody; CLU1 antibody; CLU2 antibody; CLUS_HUMAN antibody; Clusterin alpha chain antibody; Clusterin antibody; Clusterin beta chain antibody; Complement associated protein SP 40 40 antibody; Complement associated protein SP 40 antibody; Complement associated protein SP40 antibody; Complement cytolysis inhibitor a chain antibody; Complement cytolysis inhibitor antibody; Complement cytolysis inhibitor b chain antibody; Complement lysis inhibitor antibody; Complement-associated protein SP-40 antibody; D14Ucla3 antibody; Dimeric acid glycoprotein antibody; Glycoprotein 80 antibody; Glycoprotein III antibody; GP80 antibody; Ku70-binding protein 1 antibody; KUB 1 antibody; KUB1 antibody; MGC24903 antibody; NA1/NA2 antibody; RATTRPM2B antibody; SGP 2 antibody; SGP2 antibody; SP 40 antibody; SP40 antibody; Sugp-2 antibody; Sulfated glycoprotein 2 antibody; Testosterone repressed prostate message 2 antibody; Testosterone-repressed prostate message 2 antibody; TRPM 2 antibody; TRPM-2 antibody; TRPM2 antibody; TRPM2B antibody; Trpmb antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Biotin |
| Immunogen | Recombinant human Clusterin protein (23-224AA) |
| Isotype | IgG |
| Target | CLU |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | P10909 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. |
| Supplier | Cusabio |
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