Cocktail: Mouse anti-UPIII (AU1) & Rabbit anti-UP II (Polyclonal)
| Product Name | Cocktail: Mouse anti-UPIII (AU1) & Rabbit anti-UP II (Polyclonal) |
|---|---|
| Description | Cocktail: Mouse anti-UPIII (AU1) & Rabbit anti-UP II (Polyclonal) |
| Host | Rabbit and Mouse |
| Clonality | Polyclonal |
| Immunogen | UPII: Peptide-KLH conjugate. UPIII: Raised in mouse using AUM preparation from bovine urinary bladder as the immunogen. |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:50-1:100) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | lot specific |
| Storage | 2-8°C |
| Notes | Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, Uroplakin II/III cocktail is specific for tumors of urothelial origin and, when used in combination with other markers, can aid in the diagnosis of primary and metastatic tumors. |
| References | Moll et al. Am J Pathol 1995;147:1383-1397. Olsburgh et al. J Pathol 2003;199:41-49. Parket et al. 2003;27:1-10. Ohtsuka et al. 2006;97:1322-1326 |
| Supplier | MONOSAN |
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