| Product Name | COMP Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to COMP |
| Synonyms | cartilage oligomeric matrix protein (pseudoachondroplasia; epiphyseal dysplasia 1; multiple) antibody; Cartilage oligomeric matrix protein antibody; Cartilage oligomeric matrix protein precursor antibody; COMP antibody; COMP_HUMAN antibody; EDM 1 antibody; EDM1 antibody; EPD 1 antibody; EPD1 antibody; Epiphyseal dysplasia 1 antibody; Epiphyseal dysplasia 1 multiple antibody; Epiphyseal dysplasia multiple 1 antibody; MED antibody; MGC13181 antibody; MGC149768 antibody; PSACH antibody; pseudoachondroplasia (epiphyseal dysplasia 1; multiple) antibody; Pseudoachondroplasia antibody; THBS 5 antibody; THBS5 antibody; Thrombospondin 5 antibody; Thrombospondin-5 antibody; Thrombospondin5 antibody; TSP5 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Cartilage oligomeric matrix protein (20-160AA) |
| Isotype | IgG |
| Target | COMP |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | P49747 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. |
| Supplier | Cusabio |
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