| Product Name | Complement C1q |
|---|---|
| Description | C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin. The sites are on the CH2 domain of IgG and, it is thought, on the CH4 domain of IgM. The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity. Product Code:13-3022Product:Complement C1q Background:C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin. The sites are on the CH2 domain of IgG and, it is thought, on the CH4 domain of IgM. The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.Synonyms:C1qSource:Human Serum. Blood sample from donors was tested and found negative for HBsAg, HIV-1&2 antibodies, HCV and SyphilisPurity:>98% by SDS PAGEForm:Purified Antigen, in 0.01M sodium EDTA, 0.3 M NaCl, pH 7.5 Some turbidity may occur.Concentration:1 mg/ml Storage:-20C (aliquot) Notes:Because no test method can offer complete assurance that products derived from human source will not transmit infectious agents, it is recommended that this product be handled with the same precautions used for patient specimens. |
| Synonyms | C1q |
| Form | Purified Antigen, in 0.01M sodium EDTA, 0.3 M NaCl, pH 7.5 Some turbidity may occur. |
| Concentration | 1 mg/ml |
| Purity | >98% by SDS PAGE |
| Storage | -2°C (aliquot) |
| Notes | Because no test method can offer complete assurance that products derived from human source will not transmit infectious agents, it is recommended that this product be handled with the same precautions used for patient specimens. |
| Background | C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin. The sites are on the CH2 domain of IgG and, it is thought, on the CH4 domain of IgM. The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity. |
| Supplier | ARP |
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