| Product Name | Cortistatin 14 |
|---|---|
| Description |
Cortistatin 14 is an endogenous neuropeptide that has structural and functional similarities to somatostatin 14. Cortistatin 14 shows potency at all five somatostatin receptors (sst1 - sst5) and prevents somatostatin 14 from binding to them (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Cortistatin 14 has neuronal depressant and sleep modulating properties and co-exists with GABA within the cortex and hippocampus. Cortistatin 14 also binds with much lower potency to the ghrelin and MRGPRX2 receptors. |
| Synonyms | CST-14 |
| Molecular Weight | 1721.03 Da |
| Target | Mas-related G protein-coupled receptors,Somatostatin receptors |
| Amino Acid Sequence | PCKNFFWKTFSSCK |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 193829-96-8 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Disulfide bridge between cysteine 2 and cysteine 13 |
| References |
Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157 PMID: 9125122Jiang et al (2018) The role of Cortistatin-14 in the gastrointestinal motility in mice. Pharmacol. Rep 70 355 https://doi.org/10.1016/j.pharep.2017.09.004Jiang et al (2018) Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 9 767 PMID: 30072893 Related areasAll peptides >All somatostatin receptor modulators >All endocrinology research areas >All neuroscience research areas > |
| Supplier | Isca Biochemicals Limited |
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