| Product Name | Bovine Prostaglandin G/H synthase 1 (PTGS1) ELISA Kit |
|---|---|
| Description | Bovine Prostaglandin G/H synthase 1 (PTGS1) ELISA Kit has high sensitivity and excellent specificity for detection of Bovine PTGS1. No significant cross-reactivity or interference between Bovine PTGS1 and analogues was observed. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Recent research has shown that the inhibition of COX-1 is the main reason why aspirin is effective at reducing cardiac events (as opposed to aspirin's anti-platelet aggregation effects). PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants called COX-1 and COX-3. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. This Bovine Prostaglandin G/H synthase 1 (PTGS1) ELISA Kit employs a two-site sandwich ELISA to quantitate PTGS1 in samples. An antibody specific for PTGS1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPTGS1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PTGS1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PTGS1 bound in the initial step. The color development is stopped and the intensity of the color is measured. |
| Synonyms | PTGS1, RP11-542K23.6, COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS, prostaglandin G/H synthase and cyclooxygenase, prostaglandin-endoperoxide synthase 1 |
| Method | Sandwich ELISA |
| Detection Range | Please inquire |
| Sensitivity | Please inquire |
| Reactivity | Bovine |
| Sample Types | Cell culture supernatants, Serum, Plasma, Other biological fluids |
| Gene Id | 282022 |
| Storage | 2-8°C |
| Background |
There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Recent research has shown that the inhibition of COX-1 is the main reason why aspirin is effective at reducing cardiac events (as opposed to aspirin's anti-platelet aggregation effects). PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants called COX-1 and COX-3. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. |
| Supplier | Abbkine |
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