| Product Name | Cow Protein phosphatase 1B (PPM1B) ELISA Kit |
|---|---|
| Description | PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. The deduced 479-amino acid protein shows high sequence similarity to other mammalian PP2C-beta isoforms but has an extended and unique C-terminal portion. This assay has high sensitivity and excellent specificity for detection of Bovine PPM1B. No significant cross-reactivity or interference between Bovine PPM1B and analogues was observed. |
| Synonyms | MGC21657, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX, protein phosphatase 1B|protein phosphatase 2C-like protein |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.119 ng/mL |
| Reactivity | Bovine |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. The deduced 479-amino acid protein shows high sequence similarity to other mammalian PP2C-beta isoforms but has an extended and unique C-terminal portion. |
| Supplier | Abebio |
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