| Product Name | Bovine Vitamin K-dependent protein C (PROC) ELISA Kit |
|---|---|
| Description | Bovine Vitamin K-dependent protein C (PROC) ELISA Kit has high sensitivity and excellent specificity for detection of Bovine PROC. No significant cross-reactivity or interference between Bovine PROC and analogues was observed. Protein C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme (EC 3.4.21.69) that is activated by thrombin into activated protein C (APC). The activated form (with protein S and phospholipid as a cofactor) degrades Factor Va and Factor VIIIa. It should not be confused with C peptide or c-reactive protein or protein kinase C.The protein C pathway’s key enzyme, activated protein C, provides physiologic antithrombotic activity and exhibits both anti-inflammatory and anti-apoptotic activities. Its actions are related to development of thrombosis and ischemic stroke. The protein C pathway of the coagulation of the blood involves the influences of lipids and lipoproteins and the study of the strong epidemiologic association between hyperlipidemia and hypercoagulability. This Bovine Vitamin K-dependent protein C (PROC) ELISA Kit employs a two-site sandwich ELISA to quantitate PROC in samples. An antibody specific for PROC has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPROC present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PROC is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PROC bound in the initial step. The color development is stopped and the intensity of the color is measured. |
| Synonyms | PROC, APC, PC, PROC1, anticoagulant protein C, autoprothrombinA, blood coagulation factor XIV, protein C, vitamin K-dependent protein C |
| Method | Sandwich ELISA |
| Detection Range | Please inquire |
| Sensitivity | Please inquire |
| Reactivity | Bovine |
| Sample Types | Cell culture supernatants, Serum, Plasma, Other biological fluids |
| Storage | 2-8°C |
| Background | Protein C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme (EC 3.4.21.69) that is activated by thrombin into activated protein C (APC). The activated form (with protein S and phospholipid as a cofactor) degrades Factor Va and Factor VIIIa. It should not be confused with C peptide or c-reactive protein or protein kinase C.The protein C pathway’s key enzyme, activated protein C, provides physiologic antithrombotic activity and exhibits both anti-inflammatory and anti-apoptotic activities. Its actions are related to development of thrombosis and ischemic stroke. The protein C pathway of the coagulation of the blood involves the influences of lipids and lipoproteins and the study of the strong epidemiologic association between hyperlipidemia and hypercoagulability. |
| Supplier | Abbkine |
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