| Product Name | CRABP2, 1-138aa, Human Recombinant |
|---|---|
| Description | The cellular retinoic acid-binding protein II (CRABP-II) is involved in the conversion of vitamin A into its intracellular active form retinoic acid, which regulate the genes responsible for lipid metabolism and adipocyte differentiation. CRABP2 gene is located on chromosome 1q21-23 and this region has been linked with related disorders such as familial combined hyperlipidemia (FCHL) and type 2 diabetes mellitus. Recombinant human CRABP2 was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | RBP6, CRABP-II, Cellular retinoic acid binding protein 2, CRABP2, RBP6, CRABP-II, Cellular retinoic acid binding protein 2 Cellular retinoic acid binding protein II, CRABP II, CRABPII, |
| Host | E. coli |
| Molecular Weight | 23 kDa ( 215 aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL ILTMTADDVV CTRVYVRE |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris pH 8.0 |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Astrom A., et al (1991). J. Biol. Chem. 266 (26), 17662-6 Gupta A., et al (2006). Cancer Res. 66 (16), 8100-8. |
| Background | The cellular retinoic acid-binding protein II (CRABP-II) is involved in the conversion of vitamin A into its intracellular active form retinoic acid, which regulate the genes responsible for lipid metabolism and adipocyte differentiation. CRABP2 gene is located on chromosome 1q21-23 and this region has been linked with related disorders such as familial combined hyperlipidemia (FCHL) and type 2 diabetes mellitus. Recombinant human CRABP2 was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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