| Product Name | CRF (human, rat) |
|---|---|
| Description |
CRF (human, rat) is an endogenous peptide derived from a 196-amino acid preprohormone which acts as an agonist for CRF receptors, with Ki values of 11, 44 and 38 nM for hCRF1, rCRF2a and mCRF2b respectively. CRF (human, rat) is a major regulator of the hypothalamic pituitary adrenal axis response and is a stress-related neuropeptide whose dysregulation has been associated with depression. Increased CRF (human, rat) production is also associated with Alzheimer's disease. |
| Synonyms | Corticotropin releasing factor (human, rat), Corticotropin releasing hormone, CRH |
| Molecular Weight | 4757.51 Da |
| Target | Corticotropin releasing factor receptors |
| Amino Acid Sequence | SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 86784-80-7 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Vale et al (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 213(4514) 1394 PMID: 6267699Ohmura and Yoshioka (2008) The roles of corticotropin releasing factor (CRF) in responses to emotional stress: is CRF release a cause or result of fear/anxiety? CNS Neurol Disord Drug Targets. 8(6) 459 PMID: 19811447Jiang et al (2019) Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies. Front Cell Neurosci. 13 290 PMID: 31312123 Related areasAll peptides >All corticotropin releasing factor receptor modulators >All endocrinology categories >All neuroscience categories > |
| Supplier | Isca Biochemicals Limited |
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