| Product Name | Crosstide |
|---|---|
| Description | Crosstide is a synthetic peptide derived from glycogen synthase kinase-3β (GSK-3). Crosstide functions as substrate for Akt/PKB (protein kinase B) and is also recognized by MAPKAP kinase-1 and p70S6K, Crosstide also displays similar selectivity towards PKBα, PKBβ and PKBγ isoforms. The fluorescent and biotinylated version of crosstide demonstrate similar enzymic activity. |
| Synonyms | MAPKAP, 171783-05-4 , Akt/PKB, Crosstide, GSK-3, glycogen synthase kinase-3 β, kinase, p70S6K, peptide, protein kinase B, substrate |
| Molecular Weight | 1165.2 Da |
| Target | Kinases |
| Amino Acid Sequence | GRPRTSSFAEG |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 171783-05-4 |
| Storage | Store dark, frozen and desiccated |
| Notes | Modifications: None |
| References |
Dai (2002) Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3β) at serine-9 through direct interaction Biochem. Biophys. Res. Comm. 293 (4) 1191 PMID: 12054501Baer et al (2005) Activation of a GST-tagged AKT2/PKBbeta. Biochim. Biophys. Acta 1725(3) 340 PMID: 15890450Xu et al (2005) WNK1 Activates SGK1 by a Phosphatidylinositol 3-Kinase-dependent and Non-catalytic Mechanism. J. Biol. Chem. 280 34218 PMID: 16081417 Related areasAll kinase modulators >All substrate peptides > |
| Supplier | Isca Biochemicals Limited |
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