| Product Name | CRTC1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CRTC1 |
| Synonyms | KIAA0616 antibody; CREB regulated transcription coactivator 1 antibody; CREB-regulated transcription coactivator 1 antibody; CRTC1 antibody; CRTC1_HUMAN antibody; FLJ14027 antibody; MECT 1 antibody; Mucoepidermoid carcinoma translocated 1 antibody; Mucoepidermoid carcinoma translocated protein 1 antibody; TORC-1 antibody; TORC1 antibody; Transducer of CREB protein 1 antibody; Transducer of regulated cAMP response element binding protein 1 antibody; Transducer of regulated cAMP response element-binding protein (CREB) 1 antibody; Transducer of regulated cAMP response element-binding protein 1 antibody; WAMTP1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human CREB-regulated transcription coactivator 1 protein (1-248AA) |
| Isotype | IgG |
| Target | CRTC1 |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Uniprot | Q6UUV9 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. |
| Supplier | Cusabio |
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