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|Product Name||CSDC2, 1-153aa, Human His tag|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMTSESTS PPVVPPLHSP KSPVWPTFPF HREGSRVWER GGVPPRDLPS PLPTKRTRTY SATARASAGP VFKGVCKQFS RSQGHGFITP ENGSEDIFVH VSDIEGEYVP VEGDEVTYKM CPIPPKNQKF QAVEVVLTQL APHTPHETWS GQVVGS|
|Background||CSDC2, as known as cold shock domain-containing protein C2, is RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. The cold shock domain containing proteins (CSDPs) are one group of the evolutionarily conserved nucleic acid-binding proteins widely distributed in bacteria, plants, animals, and involved in various cellular processes, including adaptation to low temperature, cellular growth, nutrient stress and stationary phase. It may play a central role in the negative regulation of histone variant synthesis in the developing brain. Recombinant human CSDC2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||37.3 kDa (323aa)|
|NCBI Accession #||NP_055275|
|Purity||> 90% by SDS-PAGE|
|References||Yang C. et al. (2012) PLoS One. 7:e32012
Park SJ. et al. (2009) Plant Cell Physiol. 50:869-878
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Cold shock domain-containing protein C2, dJ347H13.2, PIPPIN|
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