| Product Name | CSNK2A1, 1-391aa, Human |
|---|---|
| Description | CSNK2A1, also known as casein kinase II subunit alpha, are catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. It regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. CSNK2A1 may act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. Recombinant human CSNK2A1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Synonyms | Casein kinase II subunit alpha, CK2A1, CKII |
| Host | E. coli |
| Molecular Weight | 16.5 kDa (147aa), confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMMSGPV PSRARVYTDV NTHRPREYWD YESHVVEWGN QDDYQLVRKL GRGKYSEVFE AINITNNEKV VVKILKPVKK KKIKREIKIL ENLRGGPNII TLADIVKDPV SRTPALVFEH VNNTDFKQLY QTLTDYDIRF YMYEILKALD YCHSMGIMHR DVKPHNVMID HEHRKLRLID WGLAEFYHPG QEYNVRVASR YFKGPELLVD YQMYDYSLDM WSLGCMLASM IFRKEPFFHG HDNYDQLVRI AKVLGTEDLY DYIDKYNIEL DPRFNDILGR HSRKRWERFV HSENQHLVSP EALDFLDKLL RYDHQSRLTA REAMEHPYFY TVVKDQARMG SSSMPGGSTP VSSANMMSGI SSVPTPSPLG PLAGSPVIAA ANPLGMPVPA AAGAQQ |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.05M NaCl |
| Concentration | 1 mg/ml (determined by BCA assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Prudent R., et al. (2010) Cancer Res. 70:9865-9874 Deloukas P., et al. (2001) Nature. 414:865-871 |
| Background | CSNK2A1, also known as casein kinase II subunit alpha, are catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. It regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. CSNK2A1 may act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. Recombinant human CSNK2A1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Supplier | ARP |
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