| Product Name | CTLA4, 36-161aa, Human, hIgG-His tag, Baculovirus |
|---|---|
| Description | CTLA4, also known as cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM, is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Recombinant human CTLA4, fused to hIgG His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM, CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12 |
| Host | Virus |
| Molecular Weight |
47.9kDa (423aa) 40-57kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSDL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH |
| Tag | hIgG-His tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Harper K., et al. (1991) J. Immunol. 147:1037-1044. Teft WA., et al. (2006) Annu. Rev. Immunol. 24:65-97. |
| Background | CTLA4, also known as cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM, is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Recombinant human CTLA4, fused to hIgG His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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