| Product Name | CTNNA1 Monoclonal Antibody |
|---|---|
| Description | Alpha catenin is an essential component of adherens junctions that connects E-cadherin-_-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin,alpha-N-catenin,and alpha-T-catenin,which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed,alpha-N-catenin is restricted to neuronal tissue,and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers,including malignant tumours of the breast,colon,stomach,oesophagus,bladder and liver. In addition,the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis. |
| Synonyms | Alpha E catenin,Cadherin associated protein,CAP102,Catenin alpha 1,CTNNA1 |
| Host | Mouse |
| Clone | 310 |
| Immunogen | Fusion protein of CTNNA1 |
| Isotype | IgG1 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P35221 |
| Background | Alpha catenin is an essential component of adherens junctions that connects E-cadherin-_-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin,alpha-N-catenin,and alpha-T-catenin,which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed,alpha-N-catenin is restricted to neuronal tissue,and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers,including malignant tumours of the breast,colon,stomach,oesophagus,bladder and liver. In addition,the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis. |
| Supplier | Elabscience |
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