| Product Name | CUL2 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CUL2 |
| Synonyms | Cul2 antibody; CUL 2 antibody; CUL-2 antibody; CUL2 antibody; CUL2_HUMAN antibody; cullin 2 antibody; cullin homolog 2 antibody; Cullin-2 antibody; MGC131970 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from human Cullin 2. |
| Isotype | IgG |
| Target | CUL2 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IF, IHC, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q13617 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Seiji Shiraishi, J. Biol. Chem., Mar 2007; 282: 9017 - 9028. Isabelle Groulx, J. Biol. Chem., Mar 2000; 275: 8991. Dimitris Liakopoulos, PNAS, May 1999; 96: 5510. Kyungwon Huh, AACR Meeting Abstracts, Apr 2006; 2006: 1326. |
| Supplier | Cusabio |
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