| Product Name | CUL4B Monoclonal Antibody |
|---|---|
| Description | Cullin-RING ligases (CRLs) complexes participate in the regulation of diverse cellular processes,including cell cycle progression,transcription,signal transduction and development . Serving as the scaffold protein,cullins are crucial for the assembly of ligase complexes,which recognize and target various substrates for proteosomal degradation. Two cullin 4 (CUL4) proteins,CUL4A (87 kDa) and CUL4B(104 kDa),are two members in cullin family with 83% of identity. Mutations in human CUL4B are one of the major causes of X-linked mental retardation. Cul4b knockout mice demonstrated that CUL4B is indispensable for embryonic development in the mouse . |
| Host | Mouse |
| Clone | 9603 |
| Immunogen | Fusion protein of CUL4B |
| Isotype | IgG1 |
| Reactivity | Human, Rat |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.1% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q13620 |
| Background | Cullin-RING ligases (CRLs) complexes participate in the regulation of diverse cellular processes,including cell cycle progression,transcription,signal transduction and development . Serving as the scaffold protein,cullins are crucial for the assembly of ligase complexes,which recognize and target various substrates for proteosomal degradation. Two cullin 4 (CUL4) proteins,CUL4A (87 kDa) and CUL4B(104 kDa),are two members in cullin family with 83% of identity. Mutations in human CUL4B are one of the major causes of X-linked mental retardation. Cul4b knockout mice demonstrated that CUL4B is indispensable for embryonic development in the mouse . |
| Supplier | Elabscience |
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