| Product Name | Cyclophilin A, 1-165aa, Human, Recombinant |
|---|---|
| Description | Cyclophilin A (also known as Peptidylprolyl isomerase A, PPIA) encodes a member of the peptidyl-prolyl cis-trans isomerase family. They are highly-conserved cytoplasmic enzymes that accelerate protein folding. Cyclophilin A is also incorporated into many viruses, including HIV-1, where it has been speculated to be involved in functions such as viral assembly and infectivity. Recombinant human PPIA, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | Peptidylprolyl isomerase A, CYPA, CYPH, MGC12404, MGC23397, MGC117158, Cyclophilin A, Cyclosporin A binding protein, Peptidyl prolyl cis trans isomerase A, PPIA, PPIA protein, PPIase A, Rotamase A, RotamaseA, T cell cyclophilin. |
| Host | E. coli |
| Molecular Weight | 18.8kDa (175aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in phosphate-buffered Saline (PBS) , pH 7.4 |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Holzman, T.F., et al, (1991). J. Biol. Chem. 266(4): 2474-2479 Berthoux L, et al, (2005). Proc Natl Acad Sci U S A. 102(41):14849-53 |
| Background | Cyclophilin A (also known as Peptidylprolyl isomerase A, PPIA) encodes a member of the peptidyl-prolyl cis-trans isomerase family. They are highly-conserved cytoplasmic enzymes that accelerate protein folding. Cyclophilin A is also incorporated into many viruses, including HIV-1, where it has been speculated to be involved in functions such as viral assembly and infectivity. Recombinant human PPIA, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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