| Product Name | CYP1B1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to CYP1B1 |
| Synonyms | Aryl hydrocarbon hydroxylase antibody; CP1B antibody; CP1B1_HUMAN antibody; Cyp1b1 antibody; CYPIB1 antibody; Cytochrome P450 1B1 antibody; Cytochrome P450 family 1 subfamily B polypeptide 1 antibody; Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile) antibody; Flavoprotein linked monooxygenase antibody; GLC3A antibody; Microsomal monooxygenase antibody; P4501B1 antibody; Xenobiotic monooxygenase antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized peptide derived from C-terminal of human CP1B1. |
| Isotype | IgG |
| Target | CYP1B1 |
| Reactivity | Human |
| Applications | ELISA, WB |
| Form | liquid |
| Diluent Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Uniprot | Q16678 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression. Sutter T.R., J. Biol. Chem. 269:13092-13099(1994). Tang Y.M., J. Biol. Chem. 271:28324-28330(1996). Gorry M.C., Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. |
| Supplier | Cusabio |
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