| Product Name | Cys-Pexiganan |
|---|---|
| Description | Cys-Pexiganan is the broad-spectrum antibacterial pexiganan with an additional N-terminal cysteine attached. Pexiganan is a 22-amino acid analog of the naturally occurring antimicrobial magainin2, extracted from the skin of the African frog Xenopus laevis. Pexiganan exhibits in vitro broad-spectrum antibacterial activity against many clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria and is the best-studied AMP to date for therapeutic purposes. The addition of the N-terminal cysteine in Cys-pexiganan allows immobilization of pexiganan as a novel approach towards endowing material surfaces with bactericidal properties as well as attachment of fluorescent or biotin tags. |
| Synonyms | AM-230, AM230, CGIGKFLKKAKKFGKAFVKILKK-NH2, Cys-Pexiganan, H-CGIGKFLKKAKKFGKAFVKILKK-NH2, Pexiganan , additional N-terminal cysteine, antibacterial |
| Molecular Weight | 2580.35 Da |
| Target | Antibacterials |
| Amino Acid Sequence | CGIGKFLKKAKKFGKAFVKILKK-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Ge et al (1999) In Vitro Antibacterial Properties of Pexiganan, an Analog of Magainin. Antimicrob. Agents Chemother. 43(4) 782 PMID: 10103181Gottler and Ramamoorthy (2009) Structure, membrane orientation, mechanism, and function of pexiganan €” A highly potent antimicrobial peptide designed from magainin. Biochim. Biophys. Acta - Biomembranes 1788(8) 1680 PMID: 19010301RodrÃguez-Rojas et al (2020) Antimicrobial Peptide Induced-Stress Renders Staphylococcus aureus Susceptible to Toxic Nucleoside Analogs. Front. Immunol. 11 1686 PMID: 33133056Teixeira et al (2022) Tiger 17 and pexiganan as antimicrobial and hemostatic boosters of cellulose acetate-containing poly(vinyl alcohol) electrospun mats for potential wound care purposes. Int J Biol Macromol. 209(Pt A) 1526 PMID: 35469947Teixeira et al (2022) Antibacterial and hemostatic capacities of cellulose nanocrystalline-reinforced poly(vinyl alcohol) electrospun mats doped with Tiger 17 and pexiganan peptides for prospective wound healing applications. Biomaterials Advances (137) 212830 https://doi.org/10.1016/j.bioadv.2022.212830 Related areas All antimicrobial peptides >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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