| Product Name | Cytokeratin 14/16 Polyclonal Antibody |
|---|---|
| Description | KRT14 encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11.KRT14 (Keratin 14) is a Protein Coding gene. Diseases associated with KRT14 include Epidermolysis Bullosa Simplex, Koebner Type and Epidermolysis Bullosa Simplex, Recessive 1. Among its related pathways are Corticotropin-releasing hormone signaling pathway and Glucocorticoid receptor regulatory network. GO annotations related to this gene include structural molecule activity and keratin filament binding. An important paralog of this gene is KRT16. KRT16 encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.KRT16 (Keratin 16) is a Protein Coding gene. Diseases associated with KRT16 include Pachyonychia Congenita 1 and Palmoplantar Keratoderma, Nonepidermolytic, Focal. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT14. |
| Synonyms | KRT14, Keratin, type I cytoskeletal 14, Cytokeratin-14, CK-14, Keratin-14, K14, KRT16, KRT16A, Keratin, type I cytoskeletal 16, Cytokeratin-16, CK-16, Keratin-16, K16 |
| Host | Rabbit |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Cytokeratin 14/16 |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Uniprot | P02533/P08779 |
| Background |
KRT14 encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11.KRT14 (Keratin 14) is a Protein Coding gene. Diseases associated with KRT14 include Epidermolysis Bullosa Simplex, Koebner Type and Epidermolysis Bullosa Simplex, Recessive 1. Among its related pathways are Corticotropin-releasing hormone signaling pathway and Glucocorticoid receptor regulatory network. GO annotations related to this gene include structural molecule activity and keratin filament binding. An important paralog of this gene is KRT16. KRT16 encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.KRT16 (Keratin 16) is a Protein Coding gene. Diseases associated with KRT16 include Pachyonychia Congenita 1 and Palmoplantar Keratoderma, Nonepidermolytic, Focal. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT14. |
| Supplier | Elabscience |
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