| Product Name | Cytokeratin 14/17 Polyclonal Antibody |
|---|---|
| Description | KRT14 (Keratin 14) is a Protein Coding gene. Diseases associated with KRT14 include Epidermolysis Bullosa Simplex, Koebner Type and Epidermolysis Bullosa Simplex, Recessive 1. Among its related pathways are Corticotropin-releasing hormone signaling pathway and Glucocorticoid receptor regulatory network. GO annotations related to this gene include structural molecule activity and keratin filament binding. An important paralog of this gene is KRT16.This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. KRT17 (Keratin 17) is a Protein Coding gene. Diseases associated with KRT17 include Steatocystoma Multiplex and Pachyonychia Congenita 2. Among its related pathways are Glucocorticoid receptor regulatory network and Keratinization. GO annotations related to this gene include structural molecule activity and MHC class II receptor activity. An important paralog of this gene is KRT14.This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. |
| Synonyms | KRT14 |
| Host | Rabbit |
| Immunogen | Synthetic peptide from human protein |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Uniprot | P02533/Q04695 |
| Background |
KRT14 (Keratin 14) is a Protein Coding gene. Diseases associated with KRT14 include Epidermolysis Bullosa Simplex, Koebner Type and Epidermolysis Bullosa Simplex, Recessive 1. Among its related pathways are Corticotropin-releasing hormone signaling pathway and Glucocorticoid receptor regulatory network. GO annotations related to this gene include structural molecule activity and keratin filament binding. An important paralog of this gene is KRT16.This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. KRT17 (Keratin 17) is a Protein Coding gene. Diseases associated with KRT17 include Steatocystoma Multiplex and Pachyonychia Congenita 2. Among its related pathways are Glucocorticoid receptor regulatory network and Keratinization. GO annotations related to this gene include structural molecule activity and MHC class II receptor activity. An important paralog of this gene is KRT14.This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. |
| Supplier | Elabscience |
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