| Product Name | Cytokeratin/Keratin 20 |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Recombinant Cytokeratin/keratin 20 |
| Synonyms | K20, CD20, CK20, CK-20, KRT21 |
| Molecular Weight | 48,553 (calculated from sequence), 46,000 (SDS) |
| Applications | ELISA |
| Form | Lyophilized, salt balanced. |
| Purity | > 95%, SDS-PAGE |
| Storage | 4C (lyophilized); at -2°C (solution, aliquot) |
| References | Moll, et al. (1990) J. Cell Biol 111: 576-580 Moll, et al. (1993) Differentiation 53: 75-93 Hofmann, I & Franke, WW (1997) Eur. J. Cell Biol. 72: 122-132 Hatzfeld M. and Franke W.W. (1985). J. Cell Biol. 101, 1826-1841 Hatzfeld M. et al. (1987). J. Mol. Biol. 197, 237-255 |
| Background | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. |
| Supplier | ARP |
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