Cytokine receptor common subunit beta, 17-443aa, Human, Baculovirus
| Product Name | Cytokine receptor common subunit beta, 17-443aa, Human, Baculovirus |
|---|---|
| Description | CSF2RB, also known as cytokine receptor common subunit beta, is a high affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors, providing a structural basis for understanding their mechanism of activation and for the development of therapeutics. Recombinant human CSF2RB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | CD131, CDw131, IL3RB, IL5RB, SMDP5, CSF2RB |
| Host | Virus |
| Molecular Weight | 23.4 kDa (210aa), confirmed by MALDI-TOF |
| Amino Acid Sequence | WERSLAGAEE TIPLQTLRCY NDYTSHITCR WADTQDAQRL VNVTLIRRVN EDLLEPVSCD LSDDMPWSAC PHPRCVPRRC VIPCQSFVVT DVDYFSFQPD RPLGTRLTVT LTQHVQPPEP RDLQISTDQD HFLLTWSVAL GSPQSHWLSP GDLEFEVVYK RLQDSWEDAA ILLSNTSQAT LGPEHLMPSS TYVARVRTRL APGSRLSGRP SKWSPEVCWD SQPGDEAQPQ NLECFFDGAA VLSCSWEVRK EVASSVSFGL FYKPSPDAGE EECSPVLREG LGSLHTRHHC QIPVPDPATH GQYIVSVQPR RAEKHIKSSV NIQMAPPSLN VTKDGDSYSL RWETMKMRYE HIDHTFEIQY RKDTATWKDS KTETLQNAHS MALPALEPST RYWARVRVRT SRTGYNGIWS EWSEARSWDT ESVLPMWLEH HHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Hansen G., et al. (2008) Cell. 134:496-507. Mulhern TD., et al. (2000) J Mol Biol. 297:989-1001. |
| Background | CSF2RB, also known as cytokine receptor common subunit beta, is a high affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors, providing a structural basis for understanding their mechanism of activation and for the development of therapeutics. Recombinant human CSF2RB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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