| Product Name | [D-Lys3]-GHRP-6 |
|---|---|
| Description |
[D-Lys3]-GHRP-6 is a ghrelin receptor (GHS-R1a) antagonist which also binds weakly to melanocortin receptors. [D-Lys3]-GHRP-6 can decrease energy intake in lean mice, mice with diet induced obesity, and in ob/ob obese mice, and reduces the rate of gastric emptying. [D-Lys3]-GHRP-6 also blocks or reduces ethanol intake and reward seeking in animal models. |
| Synonyms | DLys, [D-Lys3]-Growth Hormone Releasing Peptide 6, [His1, D-Lys3, Lys6]-GHRP |
| Molecular Weight | 930.12 Da |
| Target | Ghrelin receptors |
| Amino Acid Sequence | HwkWfK-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 136054-22-3 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, C-terminal amide |
| References |
Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565 PMID: 9574823Gomez and Ryabinin (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res. 38(9) 2436 PMID: 25257292Mosa et al (2018) Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 314(1) R71 PMID: 28903914 Related areas All peptides >All ghrelin receptor modulators >All endocrinology research categories >All appetite regulation research categories > |
| Supplier | Isca Biochemicals Limited |
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