| Product Name | (D)-PPA 1 |
|---|---|
| Description |
(D)-PPA 1 is a programmed death protein 1/ programmed death-ligand 1 (PD-1/PD-L1) interaction inhibitor. (D)-PPA 1 binds to PD-L1 with a Kd of 0.51 μM and can inhibit interaction at a concentration of 1 mg/mL in flow cytometry experiments. (D)-PPA 1 is a hydrolysis-resistant D-peptide and can disrupt the PD-1/PD-L1 interaction in vivo, inhibiting tumour growth and prolonging survival time in mouse models. |
| Synonyms | DPPA-1 |
| Molecular Weight | 1555.67 Da |
| Target | Protein-protein interactions |
| Amino Acid Sequence | nyskptdrqyhf |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 1620813-53-7 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe |
| References |
Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671Sun et al (2018) PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer. Drug Deliv. 25(1) 1746 PMID: 30394118 Related areasAll peptides >All protein-protein interaction modulators >Cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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