| Product Name | DACH1 Monoclonal Antibody |
|---|---|
| Description | DACH1,a homologue of the Drosophila dachshund gene,is a key regulator of cell fate determination during eye,leg,and brain development in the fly. Through interacting with NCoR and Smad4,DACH1 is able to inhibit the transforming growth factor-beta (TGF-beta) signaling pathway. DACH1 can inhibit breast cancer cellular proliferation via cyclin D1,suggesting a possible role in tumor suppression. Additionally,DACH1 plays an important role in negative regulation of RANKL (Receptor activator of NF-kappaB ligand ) gene expression in marrow stromal/preosteoblast cells,and loss of DACH1 expression might be involved in endometrial cancer progression. Four isoforms of DACH1 are produced by alternative splicing,but isoform1(97-110kd) is the predominantly expressed form in tissue. This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human DACH1. |
| Synonyms | DACH,DACH1,Dachshund homolog 1,FLJ10138 |
| Host | Mouse |
| Clone | 740 |
| Immunogen | Fusion protein of DACH1 |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.1% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q9UI36 |
| Background | DACH1,a homologue of the Drosophila dachshund gene,is a key regulator of cell fate determination during eye,leg,and brain development in the fly. Through interacting with NCoR and Smad4,DACH1 is able to inhibit the transforming growth factor-beta (TGF-beta) signaling pathway. DACH1 can inhibit breast cancer cellular proliferation via cyclin D1,suggesting a possible role in tumor suppression. Additionally,DACH1 plays an important role in negative regulation of RANKL (Receptor activator of NF-kappaB ligand ) gene expression in marrow stromal/preosteoblast cells,and loss of DACH1 expression might be involved in endometrial cancer progression. Four isoforms of DACH1 are produced by alternative splicing,but isoform1(97-110kd) is the predominantly expressed form in tissue. This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human DACH1. |
| Supplier | Elabscience |
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