| Product Name | DC432 |
|---|---|
| Description | DC432 is a cell permeable analogue of BM30, also available, the first potent peptidomimetic substrate competitive inhibitor of N-terminal methyltransferase1/2 (NTMT1/2), one of a family of enzymes which methylate the α-N-terminal amines of proteins starting with the canonical X-P-K/R motif. DC432 has been made cell permeable by the addition of five arginine residues to BM30. DC432 decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells. |
| Synonyms | inhibitor of N-terminal methyltransferase1/2, DC432, EI-020, EI020, N-terminal methylation, NTMT1/2, cell permeable, peptidomimetic, substrate |
| Molecular Weight | 1313.59 Da |
| Target | Transferases |
| Amino Acid Sequence | XPKRRRRRR-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | We recommend storage desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide, X is 4-hydroxyphenylacetyl |
| References | Mackie et al (2020) Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J Med Chem. 63(17) 9512 doi:10.1021/acs.jmedchem.0c00689 |
| Supplier | Isca Biochemicals Limited |
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