| Product Name | DDB2 Antibody, Biotin conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against DDB2 conjugated to Biotin |
| Synonyms | damage-specific DNA binding protein 2 antibody; Damage-specific DNA-binding protein 2 antibody; DDB p48 subunit antibody; Ddb2 antibody; DDB2_HUMAN antibody; DDBb antibody; DNA damage-binding protein 2 antibody; UV-damaged DNA-binding protein 2 antibody; UV-DDB 2 antibody; Xeroderma pigmentosum group E protei antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Biotin |
| Immunogen | Recombinant Human DNA damage-binding protein 2 protein (1-185AA) |
| Isotype | IgG |
| Target | DDB2 |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Uniprot | Q92466 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair. |
| Supplier | Cusabio |
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