| Product Name | DDIT4L Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to DDIT4L |
| Synonyms | DDIT4L antibody; REDD2 antibody; RTP801LDNA damage-inducible transcript 4-like protein antibody; HIF-1 responsive protein RTP801-like antibody; Protein regulated in development and DNA damage response 2 antibody; REDD-2 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human DDIT4L |
| Isotype | IgG |
| Target | DDIT4L |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | Q96D03 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology. |
| Supplier | Cusabio |
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