| Product Name | DDX42 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to DDX42 |
| Synonyms | DDX42ATP-dependent RNA helicase DDX42 antibody; EC 3.6.4.13 antibody; DEAD box protein 42 antibody; RNA helicase-like protein antibody; RHELP antibody; RNA helicase-related protein antibody; RNAHP antibody; SF3b DEAD box protein antibody; Splicing factor 3B-associated 125 kDa protein antibody; SF3b125 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human ATP-dependent RNA helicase DDX42 protein (519-819AA) |
| Isotype | IgG |
| Target | DDX42 |
| Reactivity | Human |
| Applications | ELISA, IF, IHC |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | Q86XP3 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. |
| Supplier | Cusabio |
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