| Product Name | Decanoyl-RVKR-CMK |
|---|---|
| Description |
Decanoyl-RVKR-CMK is a subtilisin/Kex2p-like proprotein convertase inhibitor which blocks the activity of all seven convertases, PC1, PC2, PC4, PACE4, PC5, PC7 and furin. Proprotein convertases are involved in generating bioactive peptides and activating several enzymes and growth factors in many physiological events so have important roles in some pathologies including viral infections and cancer. Decanoyl-RVKR-CMK abolishes proET-1 processing in endothelial cells and inhibits regulated secretion of the neuronal polypeptide VGF. Decanoyl-RVKR-CMK can also inhibit cleavage of the SARS-CoV-2 spike protein by furin and blocks viral cell entry with an IC50 of 57 nM in a plaque reduction assay. |
| Synonyms | dec-RVKR-cmk, Furin Inhibitor I, decanoyl-RVKR-chloromethylketone |
| Molecular Weight | 744.42 Da |
| Target | Other proteases,Antivirals |
| Amino Acid Sequence | Decanoyl-RVKR-CMK |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 150113-99-8 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Amino terminal decanoyl, acid terminal chlororomethylketone |
| References |
Denault et al (1995) Inhibition of convertase-related processing of proendothelin-1. J.Cardiovasc.Pharmacol. 26 S47 PMID: 8587448Fugère and Day (2005) Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition. Trends Pharmacol Sci. 6 294 PMID: 15925704Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 33 108254 PMID: 33007239 Related areasAll peptides >All other protease modulators >All antivirals > |
| Supplier | Isca Biochemicals Limited |
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