| Product Name | [Des-octanoyl]-Ghrelin (human) |
|---|---|
| Description |
[Des-octanoyl]-Ghrelin (human) is the more stable, non-acylated and major circulating isoform of ghrelin (human), with a a half-life of 35 min in plasma compared with 10 minutes for acylated ghrelin. Unlike ghrelin, [des-octanoyl]-ghrelin (human) does not bind to the ghrelin receptor (GHS-R1a), or induce growth hormone release. [Des-octanoyl]-ghrelin (human) exerts negative inotropic effects in papillary muscle and displays cardioprotective activity, inhibits cell proliferation in breast and prostate cancer cell lines and promotes adipogenesis in vivo. |
| Synonyms | Des-acyl ghrelin, Unacylated ghrelin, UAG |
| Molecular Weight | 3244.51 Da |
| Target | Ghrelin receptors |
| Amino Acid Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQPR |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 313951-59-6 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Baldanzi et al (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J.Cell Biol. 159 1029 PMID: 12486113Gauna et al (2005) Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab. 90(2) 1055 PMID: 15536157Petrescu et al (2020) Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis. Sci Rep 10 16024 https://doi.org/10.1038/s41598-020-72681-5Iwakura et al (2023) Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin. Peptides 167 171050 PMID: 37392995. Related areas All peptides >All ghrelin receptor modulators >All endocrinology research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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