| Product Name | Desmin |
|---|---|
| Description | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. Recombinant Desmin from Escherichia coli |
| Molecular Weight | 53539.6 (calculated from sequence), 55,000 (SDS) |
| Applications | ELISA |
| Form | Lyophilized, salt balanced. |
| Purity | > 95%, SDS-PAGE |
| Storage | 4C (lyophilized); at -2°C (solution, aliquot) |
| References | Geisler, N. and Weber, K. (1980) Eur. J. Biochem. 111: 425 ff Hatzfeld M. and Franke W.W. (1985). J. Cell Biol. 101, 1826-1841 Hatzfeld M. et al. (1987). J. Mol. Biol. 197, 237-255 |
| Background | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21 |
| Supplier | ARP |
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