| Product Name | DFFB Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to DFFB |
| Synonyms | CAD antibody; Caspase activated deoxyribonuclease antibody; Caspase activated DNase antibody; Caspase activated nuclease antibody; Caspase-activated deoxyribonuclease antibody; Caspase-activated DNase antibody; Caspase-activated nuclease antibody; CPAN antibody; Deoxyribonuclease III, caspase activated antibody; DFF 40 antibody; DFF-40 antibody; DFF2 antibody; DFF40 antibody; Dffb antibody; DFFB_HUMAN antibody; Didff antibody; DNA fragmentation factor 40 kDa subunit antibody; DNA fragmentation factor subunit beta antibody; DNA fragmentation factor, 40 Da, beta polypeptide (caspase activated DNase) antibody; DNA fragmentation factor, 40 kD beta subunit antibody; DNA fragmentation factor, 40 kD, beta polypeptide antibody; DNA fragmentation factor, 40kDa, beta polypeptide (caspase activated DNase) antibody; OTTHUMP00000003633 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human DFFB |
| Isotype | IgG |
| Target | DFFB |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | O76075 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. |
| Supplier | Cusabio |
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