| Product Name | DHCR7 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to DHCR7 |
| Synonyms | DHCR7 antibody; D7SR antibody; 7-dehydrocholesterol reductase antibody; 7-DHC reductase antibody; EC 1.3.1.21 antibody; Delta7-sterol reductase antibody; Sterol Delta(7)-reductase antibody; Sterol reductase SR-2 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human DHCR7 |
| Isotype | IgG |
| Target | DHCR7 |
| Reactivity | Human, Mouse |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | Q9UBM7 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein. |
| Supplier | Cusabio |
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