| Product Name | Dynorphin A |
|---|---|
| Description |
Dynorphins are a class of opioid peptides that arise from the precursor protein prodynorphin, which when cleaved by proprotein convertase 2, releases multiple active peptides including dynorphin A, dynorphin B, and α/β-neo-endorphin. Dynorphin A is an endogenous kappa receptor agonist and has different physiological actions depending upon its site of production. Dynorphin A is a modulator of pain responses and also has roles in weight control, regulating body temperature, and influencing drug seeking behaviour |
| Synonyms | Dyn A 1-17, Dynorphin A (1-17), Dynorphin 17 |
| Molecular Weight | 2147.51 Da |
| Target | ΰ Opioid Receptors |
| Amino Acid Sequence | YGGFLRRIRPKLKWDNQ |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 80448-90-4 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Day et al (1998) Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity. J Biol Chem. 273(2) 829 PMID: 9422738Lai et al (2006) Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nat Neurosci. 9(12) 1534 PMID: 17115041Redila and Chavkin (2008) Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology 200(1) 59 PMID: 18575850 Related areas All peptides >All κ opioid receptor modulators >All pain research categories > |
| Supplier | Isca Biochemicals Limited |
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