| Product Name | E-cadherin Monoclonal Antibody |
|---|---|
| Description | Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin),also known as CDH1 (cadherin 1) or CAM 120/80,is a classical member of the cadherin superfamily which also include N-,P-,R-,and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding,providing specific interaction with adjacent cells,while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-,_-,_-,and _-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity,and is involved in mechanisms regulating proliferation,differentiation,and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness. |
| Synonyms | Arc 1,Cadherin 1,CAM 120/80,CD324,CDH1,CDHE,E cadherin,ECAD,E-cadherin,Epithelial cadherin,LCAM,UVO,Uvomorulin |
| Host | Mouse |
| Clone | 6B11F11 |
| Immunogen | Fusion Protein of E-cadherin |
| Isotype | IgG2b |
| Reactivity | Human, Mouse |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P12830 |
| Background | Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin),also known as CDH1 (cadherin 1) or CAM 120/80,is a classical member of the cadherin superfamily which also include N-,P-,R-,and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding,providing specific interaction with adjacent cells,while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-,_-,_-,and _-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity,and is involved in mechanisms regulating proliferation,differentiation,and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness. |
| Supplier | Elabscience |
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