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|Product Name||EBAG9, 28-213aa, Human, Recombinant|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MRSGRGRKLS GDQITLPTTV DYSSVPKQTD VEEWTSWDED APTSVKIEGG NGNVATQQNS LEQLEPDYFK DMTPTIRKTQ KIVIKKREPL NFGIPDGSTG FSSRLAATQD LPFIHQSSEL GDLDTWQENT NAWEEEEDAA WQAEEVLRQQ KLADREKRAA EQQRKKMEKE AQRLMKKEQN KIGVKLS|
|Background||Estrogen receptor binding site associated antigen 9, also known as EBAG9, is a type III transmembrane protein that is predominantly located in the Golgi. This protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers, such as advanced breast and prostate cancers. As the EBAG9 acts to inhibit the growth of receptor-binding cells and induced apoptosis of immune cells, cancer cells might evade immune surveillance. So immunodetection of EBAG9 expression can be a negative prognostic indicator. Recombinant human EBAG9 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 25 mM Tris-HCl, pH7.5, 100 mM NaCl, 5 mM DTT, 10%Glycerol.|
|Intended Use||For Research Use Only|
|Molecular Weight||41.6kDa (384aa)|
|NCBI Accession #||NP_004206|
|Purity||> 90% by SDS PAGE|
|References||Kumagai J., et al.,(2009) Int J Cancer.124(4):816-26.
Yoshida S., et al.,(2008) J Rheumatol. 35(9):1716-22.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||EB9, PDAF, RCAS1, Estrogen receptor binding site associated antigen 9, EBAG9, Estrogen receptor binding site associated, antigen 9 BAG9, Cancer associated surface antigen, Cancer associated surface antigen RCAS1, EBAG 9, Estrogen receptor binding fragment associated gene 9 protein, PDAF, RCAS 1, RCAS1, Receptor binding cancer antigen expressed on SiSo cells.|
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