| Product Name | EBI3 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to EBI3 |
| Synonyms | cytokine receptor antibody; EBI3 antibody; EBV induced gene 3 protein antibody; EBV-induced gene 3 protein antibody; Epstein Barr virus induced 3 antibody; Epstein Barr virus induced gene 3 antibody; Epstein Barr virus induced gene 3 protein antibody; Epstein-Barr virus-induced gene 3 protein antibody; IL 27 subunit beta antibody; IL 27B antibody; IL-27 subunit beta antibody; IL-27B antibody; IL27 subunit antibody; IL27 subunit beta antibody; IL27B antibody; IL27B_HUMAN antibody; IL35 subunit antibody; interleukin 27 subunit beta antibody; Interleukin-27 subunit beta antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Interleukin-27 subunit beta protein (21-227AA) |
| Isotype | IgG |
| Target | EBI3 |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | Q14213 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. |
| Supplier | Cusabio |
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